Tag Archives: FAQs

How Pertinent the Source Is

April 27th, 2012
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Matt Poteet, Pharm.D.

Q: You touched on nitrates and nitrites in passing previously. With all the reading I’ve done, I’m still confused regarding how bad these compounds are for you as well as how pertinent the source is.

I’ve also read that 80% of our nitrate intake actually comes from fresh vegetables and that a lot of the food that is “nitrate and nitrite free” actually uses celery juice which is naturally high in nitrites and therefore isn’t really “nitrite free” at all.

While a quick overview would be great, I would certainly appreciate a more involved look at the effect of nitrites and nitrates in the body, the mechanism by which the are deemed harmful, etc.

Thanks again.

A: It is a very interesting subject, and you are right in that it is confusing and conflicting because there are some confusing and conflicting data out there. Nitrates and nitrites are in the same family but seem to affect the body in different ways. Very briefly, nitrATE itself is not toxic to humans. But it is metabolized to nitrite in the body by a couple of mechanisms. Nitrites are toxic to humans, but it takes a large amount of them to be toxic by themselves. The much more worrisome reaction is the reaction between some amino acids and nitrite to form something called nitrosamines in the GI tract. Nitrosamines are known potent carcinogens and there is strong data showing increased consumption of nitrates and nitrites in cured meats and increased incidence of GI cancers. The worry is primarily with the cured meats due to high amino acid content and high potential nitrosamine formation. This worry is not present with the plants that you correctly described as having lots of nitrates in them due to the relative lack of amino acids.

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What is the Ideal Content of DHA and EPA in Fish Oil?

April 27th, 2012
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Matt Poteet, Pharm.D.

A: I prefer a higher ratio of DHA to EPA simply due to the fact that the DHA conversion is limited from EPA in the body and DHA is such a vital structural component in the central nervous system. Of course EPA is also vital for prostaglandin synthesis, so that shouldn’t be ignored. If there were a 1:1 oil I would think that to be ideal, but usually what I do is either mix cod liver (high DHA) with regular fish oil (high EPA), or simply rotate taking them on a daily basis.

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Any Tips How to Avoid This

April 27th, 2012
0
Matt Poteet, Pharm.D.

A: Eggs will not become allergenic if eaten long term. Allergies develop from an acute immunological response to a foreign protein. If its going to happen, it will happen but usually food allergies develop early on in life. You should be fine.

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Help Control Blood Sugar?

April 27th, 2012
0
Matt Poteet, Pharm.D.

A: I’m extremely impressed with berberine. I’m quite surprised we haven’t heard more about it in the US. Although the MOA is unknown it has shown significant promise in improved glucose tolerance and enhanced energy partitioning (less body fat, more lean tissue), and it has been shown to improve blood lipid profiles. You all know my thoughts on cholesterol, but if you are an individual with high LDL type b or familial hypercholesterolemia, the unique MOA of berberine makes it far more desirable as a treatment than inhibiting the mevalonate pathway via statins and the tremendous adverse effects that causes on the entire body.

Regarding cinnamon: from the studies I have read Cinnamomi cassiae extract (Cinnamon bark: Lauraceae) is the most potent form. Great results on fasting blood glucose, LDL, and triglycerides were found starting at 1 g a day. The response was somewhat dose dependent up to several grams a day, but 1 gram gave most of the benefits of the 6 g (was not linear). I would say start at 1 g.

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General Take on Supplements

April 26th, 2012
0
Matt Poteet, Pharm.D.

A: Thank you for the question. It is an excellent question and one that I get a lot so let me try to address it in a general manner. Before we get to supplements, let me say that our goals for our nutrition should start with the foundation of a diet that very closely mimics what we as a species ate for our entire history up until the proliferation of processed foods in the 20th century. We were either designed or adapted through selective pressures to thrive on a diet of natural foods, with natural meaning very minimally processed with no genetic mumbo jumbo in the DNA of the plants or animals. Most of the limited research available shows that it really isn’t very important the exact macro breakdown of the food as much as the minimal processing of the food. So 10% or 50% of carbohydrate doesn’t seem to make a big difference in the life expectancy or quality of life of people as long as the food they are eating is natural. Which brings us to the point of “what is ‘natural’ really”?

I define natural as the condition that food USED to be available as pre-industrial agriculture. Plants were full of the correct vitamins and minerals due to natural fertilization and rotational planting instead of having only a few minerals available to them for replenishment by commercial fertilizer. Commercial fertilizer does make large, good -looking fruit but it is deficient in many of the minerals that the plant should contain naturally. With animal products, animals should be raised on their natural diets in order to contain the appropriate fatty acids. Ruminants should eat grass their entire lives, fish should be caught in the wild, chickens should roam and scratch the ground, eating the insects and worms they turn up, etc. So how do you address the dietary deficiencies if you absolutely must rely on industrial food sources? Here is where supplements play a role.

Supplements in this scenario are exactly what they are named. They should be used to provide that bridge back to the natural diet that we are conditioned to thrive with. For example- magnesium, selenium, and zinc to replace the magnesium, selenium, and zinc that are supposed to be in the plants we eat, omega 3s to mimic the meat lipids that we were conditioned to eat for thousands of years, probiotics to replace the bacteria we used to consume before the advent of pasteurization, etc. In essence, we are retro-engineering our food supply back to what it is supposed to be. The only way to thrive as an organism is to consume what the organism has adapted to consume in its totality. Sure, we are adaptable organisms and can survive on many different foods and many different intake levels. But to be truly healthy and to thrive we must seek to consume our body-adapted diet.

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Nutraceutical of the Month – Turmeric

April 26th, 2012
1
Matt Poteet, Pharm.D.

Turmeric

You have probably got some of this hanging out in the back of your kitchen cabinet or spice rack gathering dust and waiting on you to cook up that Indian or Thai dish you make about twice a year. What you probably didn’t realize is what a powerful and storied nutraceutical turmeric is. As one of the most important spices of the Indian subcontinent, it has been used in their religious and medical practices for almost 3000 years. Modern medical science is confirming what India has known for all those many years; turmeric has potent pharmaceutical activity.

Most of the press has been devoted lately to the turmeric’s theoretical active ingredient, the polyphenol known as curcumin. Talk shows and supplement companies have recently touted the effects of isolated curcumin as a potent anti-inflammatory, virostatic, and anti-carcinogenic agent. The various proposed mechanisms for these potential pharmaceutical effects are diverse and significant research money would be required ( and rarely gotten in nutriceuticals) to pin down exactly what is going on biochemically. What is evident so far, at least anecdotally, is that whole turmeric is more effective than isolated curcumin at producing the desired pharmaceutical effects. This is probably due to the synergistic effect of the various curcuminoids and other natural compounds in the turmeric which have unwittingly been tossed aside in isolating the proposed “active compound” of curcumin. This falls in line with what we have generally seen since we have started isolating and testing various polyphenolic compounds; they generally fair much better synergistically at producing their health benefit than they do in isolation of the most “potent” supposed compound.  This fact reinforces my belief in the complexity and irreducibility of our food.

For potent anti-inflammatory effects and general health, try turmeric at 1-2 grams three times daily. As always, do not begin any nutraceutical or pharmaceutical if you are on other medications without first checking with your physician or local pharmacist for potential drug interactions.

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Reconstructing the Anabolic Diet- Part 1

April 26th, 2012
7 responses
Matt Poteet, Pharm.D.

It is hard to believe that it has been almost 20 years since the Anabolic Diet cycled its way into the mainstream of the sports nutrition world. I remember receiving my copy in the mail in the middle of the summer of my freshman year in college, laying at the beach and looking down at my perpetual plump-titude of a belly and thinking carbohydrates caused this, and bacon can help get rid of it? I could not imagine this to actually be the case. After all, I considered myself to be fairly well-read in the matters of science for a teenager, and in particular in the matters of bodybuilding nutrition. I don’t think I put the book down until I had completely finished it. As it turned out, did turn out to be a revolution in sports nutrition thinking. It spawned numerous copycat books, and in my opinion, paved the way for the resurgence of the “Atkins” style diet in the late 90’s. So I guess you can say it has had a good run. It has enjoyed a long and mostly successful track record with those who have tried it.

Despite its success, we have had nearly 20 years to think about the Anabolic Diet in a critical manner. It is human nature to think that we can make something better. In fact, one of the most frequent questions I get from bodybuilders over the past ten years is  how would I tweak the Anabolic Diet if I were re-writing it. It is still a fantastic diet template, but can we use the knowledge we have accumulated through 20 more years of sports nutrition research and experience on the original diet to address the shortcomings and optimize the diet. I believe we can. There is a lot it though, so this will be a three part series. In the first part, I will discuss modifications of the high fat, low carbohydrate weekday template. Part two will be the weekends, and then in part three we will dive into supplements and training timing for optimization of the diet.

Generalities

The one criticism that I have always had of the Anabolic Diet was the complete lack of details about what you are actually consuming. In some ways, Dr. Dipasquale was indeed ahead of his time in regards to macronutrient quality, in particular in the supplementation chapter. He was among the first to publicly recommend essential fatty acid supplementation in the sports nutrition arena, and was also at least a couple of years ahead of the curve when it came to supplementation with creatine as an ergogenic aid. That is no small feat considering that probably two of the top three or four supplements that every athlete uses in the 21st century are a creatine supplement and their essential fatty acid supplement. But, aside from his forward-thinking supplement recommendations the book is completely silent on macronutrient quality. Why would an essential fatty acid supplement be so important to Dr. Dipasquale when the fatty acids in the actual food that he recommended were completely ignored? According to him, it is inconsequential because the fats are being broken down as energy substrates in ketosis anyway, so it did not matter where the fatty acids came from. They would end up as ketones. Well, we know this simply isn’t true and if it was true why did he make the distinction with the essential fatty acid supplement? Of course, we know now that fatty acid quality in the diet is extremely important for the health and maintenance of almost every organ system. From proper brain and nervous system function to correct balance of inflammatory cytokines, to proper inter and intra-cellular communication the correct fatty acids in the diet are critical.

I do understand the probable reasoning behind this oversight is marketing. After all, selling a book with the shocking claim that you can “pig out on anything you want” is much easier than actually selling a book which lays out an optimal plan for health and body composition. Authors are still using this tactic to this very day. Saying something provocative, and becoming both well-known and well-off for it is the American Way it seems. But since I do not seek to be either provocative or well-known I will simply give you what I feel is the best way to structure the plan.

The major, overarching themes are mostly correct and necessary. The macronutrient ratio, in my opinion, needs to be where the original book stated that it should be; 55-60% fat, 35-40% protein, and < 5% carbohydrate throughout the week. This enables the body to run efficiently off of ketones and avoids too much gluconeogenesis from protein intake. Many people have made the mistake of eating insufficient fat and have ended up stripping dietary and skeletal protein down in this process. The dietary fat is protein sparing at levels greater than 50%, and is critical for the Anabolic Diet, or any other keotgenic diet, to work optimally.

Protein Quality- Why Bother?

The sources of animal protein are the biggest disagreement that I have with the Anabolic Diet’s weekday recommendations. In the original book, Dipasquale gave the reader a rather unlimited choice of fatty foods for the weekdays. As long as you stayed under 30 grams of dietary carbohydrate you could eat anything you wanted including loads of processed meats like bacon, breakfast sausage, bologna, potted meat, vienna sausage, and so on. As it turns out, this isn’t such a good idea. Sure, you are staying under 30 grams of carbohydrate, and are eating roughly 55% fat and 40% protein, but turn the package over and look at the mounds and mounds of the other things you are eating. Piles of nitrates and nitrates, preservatives of various kinds, and multi-syllabic chemistry experiments that I would literally need to ask a chemistry professor what they actually were. It is no wonder that I often had a mild headache and felt a little nauseous when I ate meals of that processed junk back in the early days.

This oversight is simply a symptom of the way we look at our food as a society. We see “protein, carbs, fat….protein, carbs, fat…. and then way on down the line we think about a few known vitamins and minerals. No one ever considers the other constituents of their food. And as we are finding out that is a dangerous oversight. As an example, the nitrosamines formed from the excess nitrate and nitrite interacting with the animal protein in processed meat is extremely concerning. Nitroamines are known carcinogens, and a known cause stomach cancer. How many people think about that little chemistry experiment on top of your hickory-smoked bacon?

Fats

Another example is the laisse -faire philosophy to dietary fatty acid type in the Anabolic Diet. As I mentioned earlier in the article, fatty acid composition is extremely important to the health and well-being of an athlete and any individual. The original Anabolic Diet, with its potential heavy consumption of pro-inflammatory fatty acids left many individuals with aching joints, poorer sleep, and greater potential for adverse health effects. Dr. Dipasquale also, for no reason that I can logically find, places a complete restriction on consuming medium chain triglyceride oils (coconut oil). His logic was that it “interfered with ketosis”, but that is absolutely not true. In fact, coconut oil speeds along the body’s descent into ketosis and is used in that application as a dietary supplement by many clinicians and nutritionists. Aside from that fact, coconut oil has also been shown to have a myriad of other health benefits. My recommendation is for liberal use of coconut oil while on the Anabolic Diet.

As far as the rest of the fats go, there are two broad rules that we must stick to. The first is to limit pro-inflammatory fatty acid consumption. So what is a pro-inflammatory fatty acid? We could get super-technical, but for a dieter’s purpose It is simply a highly reactive, processed fatty acid source. Chiefly I am speaking about processed vegetable oils which are high in polyunsaturated fats. Oils which have been taken out of their natural environment through expeller-pressing, hexane extraction, bleaching, and deodorizing have very little in common with the foodstuff which originated them. We will have plenty of detail about fatty acids in the future on this site.

The Fix

So, constructing a diet around the consumption of processed meats and any type of fat you want to eat isn’t the best thing for health. The great news is that this all a very simple fix. With minor changes, we can change a diet with some significant limitations into one which is both a potent weight loss diet and very healthy. All you have to do is put a few restrictions and recommendations in place for the weekdays in terms of food types. The following is how I would address these issues:

Original Anabolic Diet Dr. Matt’s Anabolic Diet
Processed Meats Unlimited- no Recommendations on consumption Limit to two servings/ week
Beef Unlimited- no Recommendations on consumption Unlimited.  Grass-finished preferable
Fish Unlimited- no Recommendations on consumption Eat at Least 2 servings/week
Pork Unlimited- no Recommendations on consumption Unlimited, un-processed cuts

Local, organic preferable

Poultry Unlimited- no Recommendations on consumption Unlimited. Skin-on

Preferably Pasture-raised

Dairy Unlimited- no Recommendations on consumption other than < 30 g carbs Raw cheeses, hard cheeses

only

Eggs Unlimited- no Recommendations on consumption Unlimited- pastured preferable
Fats Unlimited- no Recommendations on consumption. Restricts “MCT’s” Natural fats only- Coconut oil, butter, lard, tallow. Cold-pressed olive oil and sesame oil 15 g/ day maximum.

Is All of This Organic (Expensive) Meat Necessary?

The short answer to the question is no, the quality “organic” meat is not necessary to make this diet work. Your abs won’t pop any better, there will be not a single additional striation in your pecs. So why go to the trouble? Well, a couple of reasons. First and foremost, this is an article about my opinion on how to optimize the diet. Optimizing the diet includes not only physical results, but also your health. It does little good to spend your life trying to look “awesome” if you spend the last 25% of it in a hospital or with some debilitating chronic disease. Am I being an alarmist? Perhaps. But perhaps I am not and I would be able to sleep very well at night if I didn’t give you my full opinion on food quality.

Meat is more than just a “food group”. Even though it takes up only one section of the typical american plate at dinner, its impact is far greater than the vegetables, fruits, and starches that gather beside it. Meat is concentrated nutrition. In effect, it is the sum total of everything that animal had eaten and experienced in its environment during its lifetime. The animal’s body is much like ours in that it is very resilient; it is capable of dealing with many offenses and still surviving and appearing healthy. Some offenses, such as keeping the animal in cramped, unsanitary quarters do not filter down into the meat that it produces for us. Sure, there is an argument to be made for e.coli 157H7 stemming directly from these cramped and unsanitary living conditions and that is very true and a topic for another day. Speaking completely in a vacuum about internal food quality of the meat, the animal survives pretty well. Other offenses do make it into the meat. Artificial growth hormones, anabolic and estrogenic steroids, and environmental pesticides and herbicides all make it into the meat that you are eating. These lipophilic molecules are absorbed into the fatty portions of the meat and collect there over time, like a nasty Christmas present waiting for your body to open. In the case of the pesticides and herbicides, they collect over the entire lifetime of the animal, lying in wait in that juicy steak for you.

The proponents of conventional meat will say that these things have been thoroughly tested and have been found to be innocuous to humans. But the simple fact is, these substances collect in your tissues when you eat the contaminated meat as well and accumulate over years of consumption. Do you see where this is going? There simply are no long term studies on these chemicals in the amounts that we have the potential to store in our bodies over the course of many years of life. Being that many of these chemicals act upon the central nervous system of insects and other critters to produce their effects, and being that we have a nervous system as well that has a lot of chemical similarities to others in the animal kingdom, I think the wisest course of action is to greatly limit the amount of these toxins that the body is exposed to. It may turn out to be nothing, but then again it may turn out to be something big. Why take the chance with your 60 year old future self? This is even more critical on a diet like the Anabolic Diet, when meat is being consumed in large quantities. Eat natural foods whenever possible.

Conclusion

Pretty painless wasn’t it? Simple substitutions based on our current nutritional knowledge, common sense, and experience goes a long way toward making the Anabolic Diet more livable and ultimately a better-performing diet. But we are just getting warmed up. Come back for part two where we will discuss every athlete’s favorite part of the diet…the weekend

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